Understanding some common side effects that may occur with HALAVEN

Low white blood cell count (neutropenia)

A decrease in white blood cells, or neutropenia, is a side effect of HALAVEN. Your HCP should do a blood test to monitor your blood cells before you receive each dose.

Tips for managing neutropenia and preventing infection

  • Practice good hand hygiene
  • Maintain good mouth care and consider a mouth rinse with baking soda or salt and baking soda
  • Keep cuts or scrapes clean and covered
  • Avoid sources of potential bacterial infections (eg, hot tubs and rivers) and eating unpasteurized dairy or undercooked meat
  • Avoid contact with sick people or touching human or animal waste
HALAVEN treatment for metastatic breast cancer

Hair loss (alopecia)

Hair loss is a frequent concern of people with mBC during treatment. It is important to know that you do not have to go through this alone. It can be helpful to speak to others who have had a similar experience by reaching out to support groups in the mBC community.

Tips for managing alopecia

  • To prevent or reduce hair loss/thinning, avoid harsh products for your hair or scalp. Try using mild shampoo and soft brushes
  • Avoid using items that might damage your hair (dyes, sprays, or hair bands and clips)
  • Decrease frequency of hair washing
  • Consider changing your hairstyle before a potential hair loss

Numbness, tingling, or pain in your hands or feet (peripheral neuropathy)

Nerve problems, or peripheral neuropathy, are another side effect of HALAVEN. Be sure to tell your health care team if you feel numbness, tingling, or burning in your hands and feet. Your doctor may recommend lowering your dose of HALAVEN to help control this problem.

Tips for managing peripheral neuropathy

  • Avoid hot baths and drinking alcohol, which may worsen these symptoms
  • Avoid cold temperatures. Wear gloves and socks
  • Practice low-intensity activities as discussed with your health care provider (eg, yoga, walking)
  • Be careful when handling sharp objects
  • If you have diabetes, control your blood sugar levels, as high blood sugar can damage nerves

Feeling very tired (fatigue)

Fatigue is common among people with cancer. It can range from moderate to severe, and though it can be manageable, there isn’t a cure-all to treat it.

Tips for managing fatigue

  • Try to stay active by getting regular exercise (with your health care provider’s approval)
  • Drink plenty of water as tolerated (unless instructed otherwise by your doctor)
  • Eat healthy meals to give you more energy
  • Plan rest time in your daily schedule, and ask for help with difficult daily tasks or chores
  • Consider mental health counseling, stress management, and relaxation exercises to improve the feelings related to fatigue

Nausea and vomiting

Nausea and vomiting are 2 common side effects that you may experience. You can take steps to reduce these symptoms on your own or talk to your health care team about anti-nausea medicines that can help manage these symptoms.

Tips for managing nausea and vomiting

  • Limit portion size and eat several small meals instead of 3 large meals. Choose easy-to-digest food and drinks:
    • Increase fruit and vegetable intake
    • Limit high-fat products (mayonnaise, butter)
  • Avoid fried and spicy foods
  • Sip water at room temperature all day long, unless your doctor instructs you to limit fluid intake
  • Sip flat ginger ale or ginger tea

Keep track of your side effects

This information can help your health care team support you. Your doctor may lower or delay your dose of HALAVEN. If side effects do not improve, you may need to stop taking HALAVEN.

Who is HALAVEN® (eribulin mesylate) Injection for?

HALAVEN is a prescription medicine used to treat adults with breast cancer that has spread to other parts of the body, and who have already received other types of anticancer medicines after the cancer has spread.

What safety information do I need to know about HALAVEN?

HALAVEN can cause serious side effects, including

  • Low white blood cell count (neutropenia). This can lead to serious infections that could lead to death. Your health care provider will check your blood cell counts. Call your health care provider right away if you develop fever (temperature above 100.5°F), chills, cough, or burning or pain when you urinate, as any of these can be symptoms of infection
  • Numbness, tingling, or pain in your hands or feet (peripheral neuropathy). Peripheral neuropathy is common with HALAVEN and sometimes can be severe. Tell your health care provider if you have new or worsening symptoms of peripheral neuropathy
  • Your health care provider may delay or decrease your dose or stop treatment with HALAVEN if you have side effects

Before you receive HALAVEN, tell your health care provider about all of your medical conditions, including if you

  • have liver or kidney problems
  • have heart problems, including a problem called congenital long QT syndrome
  • have low potassium or low magnesium in your blood
  • are pregnant or plan to become pregnant. HALAVEN can harm your unborn baby. Tell your health care provider right away if you become pregnant or think you are pregnant during treatment with HALAVEN. Females who are able to become pregnant should use an effective form of birth control during treatment with HALAVEN and for at least 2 weeks after the final dose of HALAVEN and males should use an effective form of birth control when having sex with female partners who are able to become pregnant during treatment with HALAVEN and for 3½ months (14 weeks) after the final dose of HALAVEN
  • are breastfeeding or plan to breastfeed. It is not known if HALAVEN passes into your breast milk. Do not breastfeed during treatment with HALAVEN and for 2 weeks after the final dose of HALAVEN

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of HALAVEN?

HALAVEN can cause changes in your heartbeat (called QT prolongation). This can cause irregular heartbeats. Your health care provider may do heart monitoring (electrocardiogram or ECG) or blood tests during your treatment with HALAVEN to check for heart problems.

The most common side effects of HALAVEN in adults with breast cancer include low white blood cell count (neutropenia), low red blood cell count (anemia), weakness or tiredness, hair loss (alopecia), nausea, and constipation.

Your health care provider will do blood tests before and during treatment while you are taking HALAVEN.

For more information about HALAVEN, please see full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.